James Arnold Taylor, Mitchell Whitfield, Nolan North, Mikey Kelley, Sarah Michelle Gellar, Chris Evans, Mako, Patrick Stewart, Kevin Smith, Laurence Fishburne, Zhang Ziyi, John DiMaggio, Paula Mattioli, Kevin Michael Richardson, Fred Tatasciore
After the defeat of their old arch nemesis, The Shredder, the Turtles have grown apart as a family. Struggling to keep them together, their rat sensei, Splinter, becomes worried when strange things begin to brew in New York City.