Peter Voß, Friedrich Kayssler, Alice Brandt, Bruno Güttner, Fritz Odemar, Fritz Rasp, Lilli Schoenborn, Erich Ponto, Ernst Rotmund, Gertrud Wolle, Paul Rehkopf, Ilka Thimm, Ernst Albert Schaach, Kurt Lauermann, Klaus Pohl
Sherlock Holmes and Dr. Watson look into reports that a huge, vicious hound has killed Lord Charles Baskerville and that Lord Henry Baskerville is the next to be killed.