Toshiaki Karasawa, Etsushi Toyokawa, Takako Tokiwa, Airi Taira, Nana Katase, Hitomi Kuroki, Eiko Koike, Haruka Kinami, Yoji Tanaka, Andrew Koji, Arata Iura, Teruyuki Kagawa, Fumiyo Kohinata
Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.