Mario Merola, Antonio Sabàto, Gianni Garko, Jeff Blynn, Edmund Purdom, Sabrina Siani, Lorraine De Selle, Rik Battaglia, Andrea Aureli, John Karlsen, Franco Diogene, Lucio Montanaro, Nunzio Gallo, Marco Girondino, Marina Valadier
A revolution in Iran halts a heroin shipment, but an alliance of crime families is set on getting it to the US. They decide to run the drug through an unsuspecting network of good-natured, local smugglers in Naples, while an international anti-narcotics agent rushes to shut their operation down. Betrayals and divided loyalties lead to a final, bloody confrontation in America.