Kyrie Irving, Lil Rel Howery, Shaquille O'Neal, Chris Webber, Reggie Miller, Nate Robinson, Lisa Leslie, Erica Ash, JB Smoove, Mike Epps, Tiffany Haddish, Nick Kroll, Ashton Tyler, Aaron Gordon, Wesley Witherspoon
Uncle Drew recruits a squad of older basketball players to return to the court to compete in a tournament.