Jake Gyllenhaal, Swoosie Kurtz, Marley Shelton, Danny Trejo, John Carroll Lynch, Verne Troyer, Dave Sheridan, Brian George, Patrick Cranshaw, Stephen Spinella, Ever Carradine, Geoffrey Arend, Beetlejuice, Matthew McGrory, Bonnie Morgan
Jimmy is a young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom... who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy – bubble suit and all – treks cross-country to stop her.